LOHcancer

LOH. If there is one normal and one abnormal allele at a particular locus, as might be seen in an inherited autosomal dominant cancer susceptibility disorder ...

由 M Carullo 著作 · 2023 — Exploring the prognostic and predictive impact of genomic loss of heterozygosity (LOH) in patients with metastatic colorectal cancer (mCRC).

Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...

Loss of heterozygosity (LOH) is a common form of allelic imbalance by which a heterozygous somatic cell becomes homozygous because one of the two alleles gets ...

由 CA Nichols 著作 · 2020 · 被引用 76 次 — LOH occurs when a cancer cell that is originally heterozygous at a locus loses one of its two alleles at that locus, either by simple deletion ...

由 GL Ryland 著作 · 2015 · 被引用 161 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

由 MS Hwang 著作 · 2021 · 被引用 58 次 — Clonal loss of heterozygosity (LOH) is a widespread and irreversible genetic alteration that is exquisitely specific to cancer cells. We ...

由 X Zhang 著作 · 2021 · 被引用 38 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of ...

2023年11月15日 — In some cases, loss of heterozygosity can contribute to the development of cancer. LOH of particular genes is associated with specific cancer ...